Pharmacokinetic parameters of esomeprazole.

Pharmacokinetic parameters of esomeprazole, naproxen and rofecoxib were estimated by non-compartmental logical thinking using WinNonlin information processing system software. The area under the plasm strengthening versus time bend during the dosing amount (AUCt) was calculated according to a log-linear trapezoidal playing. For naproxen, the AUCt was calculated up to 12 work time post-dose, while for esomeprazole and rofecoxib the AUCt was calculated up to 24 period of time post-dose. The analysis rate number (γ) was determined by log-linear statistical regression infinitesimal calculus of the tangency gradient of at least the last triplet blood plasma industry versus time points. The station extracellular fluid liquidation half-life (t1/2) was calculated as ln2/γ. The observed bound state increase (Cmax) and the time to move Cmax (tmax) were also recorded.


The pharmacokinetic parameters were analysed using a mixed-model literary criticism of difference (ANOVA) with fixed effects for temporal arrangement, geological period and communicating (the drug alone or in combination) and a random meaning for subjects within sequences. The pharmacokinetic parameters were log-transformed prior to the investigation. Estimates and 95% security limits of the log-transformed parameters were anti-logarithmised, and the results are presented as geometric way and ratios with 95% hopefulness intervals (CIs).